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<snippet id="S_gnrEepM">For therapeutic protein quantification in plasma, using two stable signature peptides (SPs) is recommended for reliability, with protein-level and hybrid calibrations achieving good accuracy (error < 10%) and consistent results between SPs (deviations < 15%)</snippet>. <snippet id="S_gnrEepM">Peptide-level calibration showed significant negative biases (−23 to −62%) and discordant results between SPs</snippet>, while extended-peptide calibration showed improvements but still lacked acceptable accuracy. <snippet id="S_kjDg3lX">Bottom-up LC-MS/MS assays for monoclonal antibodies typically use two unique surrogate peptides from Fab or Fc regions for quantification with multiple reaction monitoring transitions</snippet>. <snippet id="S_BFG6czq">For antibody-drug conjugates, two peptides from the tryptic digest (one quantitative from light chain, one qualitative from heavy chain) can be used as signature peptides</snippet>. <snippet id="S_1t8pQcf">The surrogate peptide method is a prevalent approach for quantifying total antibodies in pharmacokinetic assessments, with stable isotopically labeled internal standards (SIL-IS) often used to enhance quantification accuracy</snippet>. <snippet id="S_XWxG38W">Optimized methods for human drug disposition-related proteins use a minimum of three light and two heavy peptide fragments to enhance reproducibility</snippet>.

Overall, the evidence indicates that while single signature peptides can be used in some contexts, using multiple peptides (typically two or more) provides better accuracy and reliability for therapeutic protein quantification in serum.
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Current evidence suggests that using two signature peptides is recommended over a single peptide for reliable mAb quantification in serum. A study assessing calibration approaches for monoclonal antibody quantification emphasized "the importance of using two SPs for reliability" and found single peptide calibration had "significant negative biases" and "discordant results between SPs" <snippet id=S_gnrEepM>. Practical implementations in therapeutic protein studies typically employ multiple peptides; for instance, one Fc-engineered mAb PK assay determined concentrations using "multiple reaction monitoring transitions for two unique surrogate peptides" <snippet id=S_kjDg3lX>. Similarly, an ADC quantification method used "Two peptides from the tryptic digest containing a portion of the CDR" with one as the quantitative and one as the qualitative peptide <snippet id=S_BFG6czq>. While single peptides can be detected, protein-level and hybrid calibrations with two SPs achieved "good accuracy (error < 10%) and consistent results" compared to peptide-level calibration which showed poor reliability <snippet id=S_gnrEepM>.
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<snippet id="S_SvIkmlU,S_rtPxhtT">Umbrella reviews indicate that resistance training performed in the morning versus evening yields similar hypertrophy adaptations and increases in muscle strength</snippet>, though <snippet id="S_JKFS2Wu">one 24-week study found that evening resistance training resulted in a larger muscle cross-sectional area in men</snippet>. <snippet id="S_SvIkmlU">These findings could be partially explained by similar levels of p70S6K phosphorylation observed after strength training performed in the morning or afternoon</snippet>. <snippet id="S_HhyT8Rz">Research suggests that the time of day for strength training can influence performance based on an individual's chronotype, with morning training reducing diurnal variation and evening training enhancing it</snippet>. <snippet id="S_gRYJWoz">Gender-specific effects also exist, with morning exercise in women enhancing abdominal fat loss and lower body muscle power, while evening exercise in men increasing upper body strength and endurance</snippet>. <snippet id="S_SvIkmlU,S_rtPxhtT">Despite evidence of time-of-day effects on performance (with peak acute performance around 6:00 p.m.), current findings emphasize that personal preference should guide training timing</snippet>. <snippet id="S_SvIkmlU">More research is needed to verify if differences exist between training in the morning versus evening hours, particularly regarding chronotype-specific adaptations</snippet>.
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Umbrella reviews indicate that increases in muscle strength and mass do not significantly differ between morning and evening resistance training <snippet id=S_rtPxhtT,S_SvIkmlU>. Acute performance metrics typically peak around 6:00 p.m., which may offer advantages for daily output despite similar long-term adaptations <snippet id=S_SvIkmlU>. While some evidence suggests evening training could yield larger muscle cross-sectional area in men over 24 weeks, these findings have not consistently reached statistical significance in other studies <snippet id=S_JKFS2Wu>. Performance adaptations appear more closely linked to chronotype, with athletes reporting lower perceived exertion when training at their preferred time of day <snippet id=S_HhyT8Rz>. Sex-specific responses also exist, as evening exercise increases strength in women while morning exercise benefits fat loss in the same group <snippet id=S_gRYJWoz>. Therefore, experts recommend selecting training times based on personal preference to maximize adherence given the lack of clear superiority between schedules <snippet id=S_rtPxhtT>.
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<snippet id="S_ow0RlxD,S_b61oqd3">Digital health inequities are exacerbated by socioeconomic barriers, with disparities persisting among individuals who have lower income, less education, and belong to racial or ethnic minorities</snippet>, <snippet id="S_rBaa6iD">who may lack training and competencies in consideration of digital health equity and cultural humility</snippet> when interacting with technology. <snippet id="S_krnNJsl">The Association of American Medical Colleges reported that 60% of surveyed medical schools included telemedicine in their curricula</snippet>, reflecting a consensus on essential skills for clinicians in virtual care. <snippet id="S_TwqA5Qh">However, standardized telehealth competencies for advanced practice nursing are currently missing</snippet>, despite frameworks like the Four P's (planning, preparing, providing, and performance evaluation) being developed to guide curriculum development. <snippet id="S_VrMxYXW">Structured, evidence-based training should be integrated into pre-registration qualifications to prepare graduates for telehealth roles</snippet>, with ongoing professional development needed to maintain skills in a rapidly evolving virtual environment. <snippet id="S_DUMUv4Q">Digital navigators require specific competencies in digital health and a proposed 10-hour training and certification process</snippet> to support clinical teams effectively, addressing the gap in equity-focused training for healthcare professionals.
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<snippet id=S_rBaa6iD>Providers may lack training and competencies in consideration of digital health equity and cultural humility</snippet>, while <snippet id=S_paP0n66,S_ChDg9cS>health policies must strengthen telehealth training to accommodate language barriers, cultural considerations, and varying levels of digital literacy</snippet>. <snippet id=S_TwqA5Qh>Standardized telehealth competencies for advanced practice nursing are missing, though frameworks like the Four P's Telehealth approach are being developed to guide education and practice</snippet>. <snippet id=S_VrMxYXW>Digital health training should be integrated into pre-registration qualifications to prepare graduates for telehealth roles</snippet>. <snippet id=S_DUMUv4Q>Emerging roles like digital navigators require specific training and certification to support clinical teams with technology integration</snippet>.
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<snippet id="S_PiVm5fQ">Mepiquat chloride (MC) has been applied to cotton seeds at five different doses (0, 3, 6, 9, and 12 g kg⁻¹ seed) in greenhouse experiments</snippet>, where the application <snippet id="S_PiVm5fQ">decreased shoot length but had no significant effect on dry matter production, root length, shoot:root ratio or leaf area:root length ratio</snippet>. <snippet id="S_7sCukyL">MC is commonly used in China's cotton belt and worldwide to improve fiber quality and seed yields</snippet>, with application rates up to <snippet id="S_hyBY58K">45 g ha⁻¹</snippet> showing effectiveness in controlling excessive growth. <snippet id="S_hyBY58K">Multiple applications are typically employed starting when the first bud reaches a diameter of 3 mm, 6 to 10 days after bud formation begins</snippet>, and <snippet id="S_hyBY58K">optimal efficacy occurs at 30 ºC during the day and 20 ºC at night</snippet>. <snippet id="S_12ZluAp">Split dose applications at 34, 47, and 62 days after emergence have also been evaluated in field conditions</snippet>, with increasing doses causing decreasing plant height, nodes, and branching. While MC improves lint yield under certain conditions, <snippet id="S_PiVm5fQ">the seed-applied form is not expected to have a deleterious effect on plant water acquisition</snippet>.
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<snippet id="S_PiVm5fQ">Mepiquat chloride (MC) has been studied as a cotton seed treatment, with greenhouse experiments applying doses of 0, 3, 6, 9 and 12 g kg -1 seed</snippet>. <snippet id="S_PiVm5fQ">The application of MC to cotton seeds decreased shoot length but had no significant effect on dry matter production, root length, shoot:root ratio or leaf area: root length ratio</snippet>. <snippet id="S_PiVm5fQ">Thus, the application of MC to cotton seeds is not expected to have a deleterious effect on plant water acquisition</snippet>. <snippet id="S_7sCukyL">MC is commonly used worldwide as a growth regulator to improve fiber quality and seed yields</snippet>. <snippet id="S_hyBY58K">For foliar applications, MC is effective at reducing plant height up to 45 g ha −1</snippet>, though seed treatment studies used much lower rates (up to 12 g per kg seed). <snippet id="S_12ZluAp">At higher foliar doses (50-125 g ha -1), MC reduces plant height, leaf area, total above ground dry matter and number of bolls</snippet>.
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<snippet id="51627,69934,74289">Amy Tan's 1989 novel The Joy Luck Club centers on fraught mother–daughter bonds shaped by immigration, cultural clash, and generational gaps</snippet>. <snippet id="69934,74289">Central themes include mother–daughter relationships marked by differing cultural expectations, where mothers' traditional Chinese values and traumatic pasts clash with daughters' American identities and desires for independence</snippet>. <snippet id="51627">The novel explores identity, rebellion, and misunderstanding as daughters navigate their American identity while mothers relay immigrant trauma, sacrifice, and Chinese values</snippet>. <snippet id="74289">Power, identity, and female agency across migration are recurrent motifs, with resolution coming through empathy and reclaimed histories</snippet>. <snippet id="51627,69934">Stories move from resentment to partial reconciliation as daughters recognize their mothers' intentions and shared histories</snippet>.
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<snippet id="51627,69934,74289">Amy Tan's The Joy Luck Club is a 1989 novel that centers on fraught mother‑daughter bonds shaped by immigration, cultural clash, and generational gaps</snippet>. <snippet id="69934,74289">The novel weaves interlocking stories about four Chinese immigrant mothers and their four American-born daughters, with central themes of cultural and generational conflict</snippet>. <snippet id="51627,74289">Mothers relay immigrant trauma and Chinese values while daughters struggle with American identity, rebellion, and misunderstandings</snippet>. <snippet id="69934,74289">The narrative moves toward reconciliation through communication, empathy, and revisiting pasts</snippet>. This work satisfies the criteria of a late twentieth-century novel explicitly focused on troubled maternal relationships with cultural and generational tensions.
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The provided search results do not contain specific scRNA-seq data on ketamine-induced cell-type-specific transcriptional changes in mouse prefrontal cortex or hippocampus <snippet id="S_iTfCBaw,S_386ZR9h,S_KNwlTux">These snippets describe general scRNA-seq/snRNA-seq technologies and their applications to mouse brain regions but lack ketamine-specific findings</snippet>. One study discusses WNT signaling effects on cortical neuronal spine maturation in Tbr1 mutants, with implications for understanding ketamine effects on PFC and hippocampus, but does not report ketamine treatment results <snippet id="S_EVwyDNd">The study focuses on WNT signaling impact on cortical neuronal spine maturation and synaptogenesis in Tbr1 mutants, with implications for understanding neuronal development in the context of ketamine effects on the prefrontal cortex and hippocampus</snippet>. Another snippet mentions single-nucleus transcriptomics of PFC in major depressive disorder implicating oligodendrocyte precursor cells and excitatory neurons, but does not address antidepressant responses <snippet id="S_sBVDz14">We sequenced ~80,000 nuclear transcriptomes from the prefrontal cortex of MDD cases and psychiatrically healthy controls and identified cell-type-specific differentially expressed genes (DEGs). These results point to gene expression changes in predominantly two cell types: OPCs and deep layer excitatory neurons</snippet>. While these results demonstrate scRNA-seq applications to mouse brain cell type characterization, none provide the specific quantitative and mechanistic findings on ketamine/SSRI-induced transcriptional changes that the agent is seeking <snippet id="S_386ZR9h,S_qnEFPDZ">Studies utilized snRNA-seq to analyze cell type composition in adult mouse brain but do not report drug administration effects</snippet>.
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<snippet id="S_iTfCBaw,S_386ZR9h,S_hu2Og7m">The provided search results do not contain scRNA-seq evidence on cell-type-specific transcriptional changes in mouse brain regions after antidepressant administration</snippet>. <snippet id="S_iTfCBaw">While some snippets compare snRNA-seq and scRNA-seq methodologies in mouse cortex, they do not include antidepressant treatment data</snippet>. <snippet id="S_386ZR9h">One study profiles 4,388,420 nuclei across 92 mouse brain locations but only mentions ketamine as a potential substance of interest without providing actual treatment results</snippet>. <snippet id="S_hu2Og7m">Another snippet discusses rodent models for psychiatric disorders and mentions scRNA-seq as a tool, but provides no specific ketamine or SSRI transcriptional findings</snippet>. <snippet id="S_sBVDz14">Human MDD post-mortem snRNA-seq data is presented instead of mouse antidepressant intervention studies</snippet>. To obtain the specific evidence you need, a new search targeting antidepressant treatment timepoints and cell-type DEGs in mouse PFC/hippocampus would be required.
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<snippet id="S_vKl66cs,S_t1UFtY4">Community-led adaptive reuse initiatives in the Netherlands are supported by supportive legislation such as the 2010 'crisis and recovery act' which allows temporary use of buildings and integrates cultural history into land use plans</snippet>, <snippet id="S_vKl66cs">with local authorities shifting from direct investors to facilitators promoting public-private financing and partnerships</snippet>. <snippet id="S_t1UFtY4,S_0hvikSw">The Dutch governmentwide circular economy programme aims for 50% circularity in the building sector by 2030, with adaptive reuse reducing raw material use, energy consumption, waste, and carbon emissions</snippet>. <snippet id="S_kl9jhfa">A study of 53 adaptive reuse cases since 2014 revealed a significant rise in commercial and residential uses of repurposed buildings, addressing housing shortages while maintaining 96% stakeholder recognition of adaptive reuse's importance for preserving cultural values</snippet>. <snippet id="S_ZEzeufE">Notable projects include the Westergasfabriek in Amsterdam transformed into a recreational space and the HAKA building in Rotterdam repurposed into offices using demolished materials, showcasing functionalist architecture</snippet>. <snippet id="S_R69NOII">However, there is a noted disconnect between preservation of cultural values and perceived importance of circularity performance, with only 65% of cases reporting public engagement during early stages of reuse projects</snippet>. <snippet id="S_t1UFtY4">The economic recession from 2008-2014 prompted a shift from state funding to private and civic investments, impacting the heritage sector negatively but leading to enhanced adaptive reuse as a viable solution</snippet>.
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In the Netherlands, <snippet id="S_vKl66cs,S_t1UFtY4">community-led adaptive reuse is supported by policies such as the 2010 'crisis and recovery act' that reposition local authorities as facilitators</snippet>, while <snippet id="S_R69NOII">public engagement rates reached 65% of cases following the 2016 'heritage act'</snippet>. Economically, these initiatives address housing shortages through mixed funding models, with <snippet id="S_kl9jhfa">96% of stakeholders affirming the importance of preserving cultural values</snippet>. Environmentally, <snippet id="S_t1UFtY4">the national targets 50% circularity in the construction sector by 2030</snippet>, <snippet id="S_0hvikSw">achieved through reuse practices that reduce waste and carbon emissions</snippet>. Socially, <snippet id="S_ZEzeufE">projects like Amsterdam's Westergasfabriek transform heritage into spaces enhancing community wellbeing</snippet>, though <snippet id="S_R69NOII">current circularity performance often neglects broader socio-economic factors</snippet>.
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<snippet id="S_Q6ina6d">A study on blended teaching methodologies using the ARCS model implemented a motivational framework with 36 questions on the Instructional Material Motivation Survey (IMMS) to measure students' motivation in an online environment</snippet>, though this research focused on IT in Business undergraduates rather than nursing or health professions. <snippet id="S_hX0trSo">Another study found that blended learning smoking cessation intervention significantly enhanced nursing students' autonomous motivation and perceived competence</snippet>, demonstrating the application of blended learning in nursing education. <snippet id="S_N6iFqRQ">A separate study examined online learning effects on nursing students and used motivation as a variable of analysis with 164 participants</snippet>, but this research did not employ the ARCS model or IMMS instruments. <snippet id="S_sojw4wD">Additional research noted that blended learning combined with flipped classrooms allows nursing students to become self-directed autonomous learners, enhancing nursing competencies</snippet>. None of the retrieved snippets explicitly document the use of IMMS or ARCS measures (Attention/Interest subscales) with nursing students in blended or e-learning contexts.
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One search result confirms the application of the ARCS model using the Instructional Material Motivation Survey (IMMS) in a blended learning context, but the study participants were enrolled in IT in Business courses rather than health professions <snippet id=S_Q6ina6d>. While multiple studies document the use of blended learning and motivation strategies within nursing education, including enhanced autonomy and academic achievement <snippet id=S_hX0trSo,S_Nv2DGCg>, none of the provided text explicitly identifies the use of the IMMS or CIS instruments for nursing or health professional students. Several papers investigate motivation regulation and perceptions in nursing students during online learning periods <snippet id=S_N6iFqRQ,S_CMEh2Zj>, and interprofessional training utilizes blended formats for medical and nursing trainees <snippet id=S_lC2vafv>. However, the direct operationalization of 'interest' via ARCS/IMMS in nursing-specific samples is not supported by the current search snippets, as the IMMS evidence is limited to general undergraduate contexts in this set <snippet id=S_Q6ina6d>.
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<snippet id="S_aUWw0r7,S_6tLta3F">Knowledge graphs have been implemented for Electronic Health Records (EHRs) using datasets like MIMIC III, where data is mapped to ontologies using text refinement and Protege</snippet>, <snippet id="S_aUWw0r7">then a knowledge graph is created using GraphDB with SPARQL queries to retrieve and analyze information</snippet>. <snippet id="S_7vrGXF4">This implementation reduces query execution time to less than 0.15 s, enhancing decision-making and allowing integration of patient-generated data, genetic data, and socioeconomic determinants</snippet>. <snippet id="S_H6H06tT">The EHR knowledge graph has the potential to revolutionize decision-making in healthcare settings, leading to more efficient and effective patient care</snippet>. <snippet id="S_6tLta3F">The study describes the ontology creation using OWL in Protege, the RDF mapping procedure to convert data to the ontology, and building the knowledge graph using GraphDB</snippet>. <snippet id="S_Bp6t1md">Additional research includes an EHR-Oriented Knowledge Graph System toward efficient utilization of non-used information buried in routine clinical practice</snippet>. However, the provided snippets do not specifically address virtual knowledge graph approaches, semantic data dictionaries, or linked codebooks for medical measurements.
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<snippet id="S_aUWw0r7,S_6tLta3F">Knowledge graph implementations have been developed for EHR data, including mapping datasets like MIMIC III to ontologies using Protege and creating knowledge graphs using GraphDB via RDF mapping procedures</snippet>. However, <snippet id="S_aUWw0r7,S_6tLta3F">these approaches described involve materializing knowledge graphs rather than virtual/ontology-based data access (OBDA) where relational data is accessed through mappings without materialization</snippet>. The snippets do not provide evidence of virtual knowledge graph implementations using OBDA tools like Ontop or R2RML specifically for medical measurements. <snippet id="S_7vrGXF4">The implementations reduce query execution time to less than 0.15 s</snippet> and enable integration of patient outcomes and risk factor analysis. <snippet id="S_Bp6t1md">An EHR-Oriented Knowledge Graph System has also been proposed for utilizing non-used information in clinical practice</snippet>. The available snippets do not demonstrate semantic data dictionary frameworks or linked codebook approaches integrated with OBDA/virtual KG access for medical measurements specifically.
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<snippet id="S_8sUXQxV">Precipitation is the most commonly used method for extracting metals after leaching in hydrometallurgical recycling, though co-precipitation of lithium can cause total losses up to 30%</snippet>. <snippet id="S_8sUXQxV">Solvent extraction (SX) is highly effective for selective removal of elements like Co, Ni, Al, and Mn, reducing overall lithium losses to 15% after refining</snippet>, <snippet id="S_I12FLcH">where selective solvent extraction with tailored organic extractants can sequentially precipitate metals such as nickel using dimethylglyoxime and manganese using D2EHPA</snippet>. <snippet id="S_MqwIWhe">Alternative precipitation agents like sodium phosphate and potassium phosphate show efficiency correlations with process temperature and stoichiometric factors</snippet>. <snippet id="S_aewi150">Ion exchange technology presents significant challenges with high energy consumption and acid waste production, currently limiting global recycling rates to less than 6%</snippet>, <snippet id="S_aewi150">though nanofiltration membranes show promise for separating lithium from multivalent transition metal cations in battery leachates</snippet>. <snippet id="S_0C7XVAE">Hydrometallurgical processes typically involve acid leaching followed by refining through precipitation, cementation, solvent extraction, electrowinning, and ion exchange</snippet>.
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<snippet id="S_8sUXQxV">Precipitation as lithium carbonate is currently the most commonly used method to recover lithium after hydrometallurgical leaching of LIBs, but it can cause total lithium losses up to 30% due to co-precipitation with other metals</snippet>, while <snippet id="S_8sUXQxV">solvent extraction methods are highly effective at reducing lithium losses to 15% overall by selectively removing elements like Co, Ni, Al, and Mn before lithium precipitation</snippet>. <snippet id="S_I12FLcH">Selective solvent extraction using immiscible organic extractants is widely employed, where metals like nickel, manganese, cobalt, and lithium can be sequentially separated using reagents such as dimethylglyoxime, D2EHPA, ammonium oxalate, and sodium carbonate</snippet>. <snippet id="S_MqwIWhe">Recent research compares classic sodium carbonate precipitation with alternative agents like sodium phosphate and potassium phosphate, investigating temperature and stoichiometric factors to improve efficiency</snippet>. <snippet id="S_aewi150">Ion exchange technology presents significant challenges including high energy consumption and acid waste production, contributing to only 6% of batteries being recycled globally</snippet>, but <snippet id="S_aewi150">nanofiltration membranes are emerging as innovative selective technologies that can effectively remove multivalent cations like Mg²⁺ and Ca²⁺ from leachates, improving lithium yield while reducing acid production</snippet>. <snippet id="S_zrllGPw">Hydrometallurgy remains widely used for lithium recovery with low equipment investment costs, though its suitability varies with battery chemical composition and operational scale</snippet>.
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<snippet id="S_ep51C66">A typical adult human has approximately 8 to 12 pints (about 4.5 to 6.8 liters) of blood circulating through their body</snippet>, and <snippet id="S_6ZepFD3">the blood volume is about 78 ml per kilogram (about 6.7 litres for a man weighing 86 kg)</snippet>. <snippet id="S_SoTD265">Most sources state the volume of blood in an average human adult, who is between 150 to 160 pounds, as between 4.7 and 5 liters</snippet>, while <snippet id="S_h22XXil">a typical adult has a blood volume of approximately 5 liters</snippet>. This confirms the 5-liter average with a range of 4.5-6.8 liters for typical adult blood volume.
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Britannica states that a typical adult human has approximately 8 to 12 pints (about 4.5 to 6.8 liters) of blood circulating through their body <snippet id="S_ep51C66">. Another Britannica source indicates blood volume is approximately 78 ml per kilogram, which equals about 6.7 litres for a man weighing 86 kg <snippet id="S_6ZepFD3">. For a 154-pound person, Britannica estimates about 5.5 liters of blood <snippet id="S_QOkX4rw">. This aligns with other authoritative sources, including Wikipedia, which states a typical adult has a blood volume of approximately 5 liters <snippet id="S_h22XXil">. The Physics Factbook also notes that most sources state the volume of blood in an average adult (150 to 160 pounds) is between 4.7 and 5 liters <snippet id="S_SoTD265">. Together, these sources confirm that approximately 5 liters is the commonly cited average for adult blood volume.
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<answer>
<snippet id="S_AMKgb7w">Alpha-Mn bcc derived I-43m tetrahedral sites have an interstitial fraction (IF) ranging from 0.0 to 1.0, with 12 tetrahedral interstitial sites per unit cell</snippet>, confirming explicit tetrahedral displacement in this cubic structure. <snippet id="S_xHv2FdY">Tetrahedral interstitial sites in the bcc lattice are inherently non-regular and induce tetragonal distortion</snippet>, consistent with the agent's goal of identifying near-BCC structures with reduced symmetry due to tetrahedral occupancy. <snippet id="S_Z3bEhFs">Tetrahedral interstitial Mn in As is more stable than Mn in other configurations by 0.16-0.31 eV</snippet>, demonstrating that tetrahedral sites can be stable in bcc-derived frameworks. However, <snippet id="S_cLXRF0f">phosphorus interstitials show tetrahedral sites are unstable at 1.2 eV higher than quasi-hexagonal sites</snippet>, indicating site stability depends on specific element combinations. These snippets support alpha-Mn as a cI58 (I-43m) structure with explicit tetrahedral interstitial features and reduced local symmetry compared to ideal BCC (Im-3m).
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<answer>
Alpha-Mn is identified as a bcc-derived cubic structure with I-43m symmetry that explicitly features tetrahedral interstitial sites <snippet id=S_AMKgb7w>. Its unit cell is noted to have 12 tetrahedral interstitial sites, where the interstitial fraction ranges from 0.0 to 1.0 in the studied system <snippet id=S_AMKgb7w>. Supporting this structural distinction, the tetrahedral interstitial sites in the bcc lattice are described as non-regular and exhibiting tetragonal symmetry <snippet id=S_xHv2FdY>. This deviation from ideal symmetry confirms that occupancy or displacement toward tetrahedral sites reduces the symmetry below the standard BCC Im-3m structure <snippet id=S_xHv2FdY>.
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<snippet id="S_Hn8S1xo,S_ipB4qty,S_mL0KRC8">The CLARITY-AD trial enrolled 1795 participants randomized 1:1 to receive 10 mg/kg biweekly lecanemab or placebo for 18 months, with 1795 participants having MCI or mild AD diagnosed using NIA-AA criteria</snippet>. <snippet id="S_Hn8S1xo,S_ipB4qty,S_p20O8Yh">Lecanemab significantly slowed CDR-SB decline by 0.45 points (27% relative effect) compared to placebo, with a 95% CI of −0.67 to −0.23 for the difference</snippet>. <snippet id="S_Hn8S1xo">The trial also showed significant reductions in amyloid PET plaque levels (−55.48 centiloid change) and ADAS-Cog14 (−1.44 points)</snippet>. <snippet id="S_Hn8S1xo,S_ipB4qty,S_VxjMD7K">Common AEs included infusion reactions (26.4% vs 7.4%), ARIA-H (16.9% vs 8.9%), and ARIA-E (12.6% vs 1.7%) in the lecanemab versus placebo groups, respectively</snippet>. <snippet id="S_Hn8S1xo,S_ipB4qty,S_mL0KRC8">APoE ε4 carriers had higher ARIA incidence, with ARIA-H at 14% versus 9.0% and ARIA-E at 10.9% versus 1.7% for heterozygotes, and 39% versus 32.6% for homozygotes</snippet>. <snippet id="S_ipB4qty">Isolated symptomatic ARIA-H was 0.7% in lecanemab versus 0.2% in placebo, while symptomatic ARIA-E was 2.8% versus 0% in lecanemab versus placebo</snippet>.
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<answer>
<snippet id=S_Hn8S1xo,S_ipB4qty,S_i9d1QdD>The CLARITY-AD trial primary endpoint showed lecanemab reduced CDR-SB decline by 0.45 points (27% relative slowing) compared to placebo over 18 months, with scores changing by 1.21 versus 1.66 respectively.</snippet> <snippet id=S_ipB4qty,S_VxjMD7K>Overall ARIA-E rates were 12.5-12.6% for lecanemab versus 1.7% for placebo, while ARIA-H rates were approximately 17% for lecanemab versus 8.7-9.0% for placebo.</snippet> <snippet id=S_ipB4qty>Symptomatic events were observed in 2.8% for ARIA-E and 0.7% for ARIA-H in the lecanemab group.</snippet> <snippet id=S_Hn8S1xo>APOE ε4 homozygotes faced the highest risks with 32.6% ARIA-E and 39% ARIA-H incidence, compared to 10.9%/14% for heterozygotes and 5.4%/11.9% for non-carriers.</snippet>
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<snippet id="S_MvO6XoQ">A meta-analysis indicated a medium interleaving effect (Hedge's g = 0.67) in education, requiring 75 participants for detection, with 150 Dutch students (99 from research universities, 45 from applied sciences) recruited to explore study strategies on long-term retention</snippet>. <snippet id="S_JXQqQJ9">Brunmair and Richter (2019) found robust evidence that interleaving is more effective than blocking, with an intermediate effect size (Hedges' g = 0.42), though several moderators exist such as retention interval length and material characteristics</snippet>. <snippet id="S_6doaVxd">A three-way repeated measures ANOVA showed that participants' performance in spaced (interleaved) study was significantly better than massed study in both short and long-term retention conditions, with F(1, 38) = 17.43, p < .001, and  P 2 = .31</snippet>. <snippet id="S_HjbjDyG">Interleaving enhances long-term retention by promoting discriminative-contrast learning, despite students perceiving it as more difficult, with effective interventions like spaced retrieval further improving retention</snippet>. <snippet id="S_oqb2O6f">Interleaving is described as "unpopular with students but shown to be successful" for medical education, with evidence suggesting it promotes knowledge gain and retention when combined with other expanded-retrieval platform features</snippet>. <snippet id="S_avfxf73">Interleaving increases the likelihood of mastery and memory by forcing the brain to reconcile relationships between related but different areas of study</snippet>.
</answer>

<answer>
Meta-analytic evidence indicates interleaving produces robust effects in education, with Brunmair and Richter (2019) finding an intermediate effect size (Hedges' g = 0.42) favoring interleaving over blocked study <snippet id=S_JXQqQJ9>, while another meta-analysis reported a medium effect (Hedge's g = 0.67) in education contexts <snippet id=S_MvO6XoQ>. Multiple studies confirm interleaving enhances long-term retention, with one experiment showing significantly better performance after a week's delay compared to massed study (F(1, 38) = 17.43, p < .001, ηp² = .31) <snippet id=S_6doaVxd>. The effect is moderated by retention interval length, material characteristics, and type of learning material, with interleaving being most effective for categories showing subtle rather than pronounced differences <snippet id=S_JXQqQJ9>. In higher education contexts, research with 150 Dutch university students found interleaving strategies impact long-term retention outcomes <snippet id=S_MvO6XoQ>. However, students often perceive interleaving as more difficult despite its superior effectiveness for long-term retention <snippet id=S_HjbjDyG,S_oqb2O6f>.
</answer>


<answer>
<snippet id="S_AmYsVOa,S_R0Q0yol">Serum and plasma exosomes contain diagnostic biomarkers for colorectal cancer metastasis, with exosomal CEA showing an AUC of 0.9354 for predicting distant metastasis, superior to serum CEA (AUC 0.8557)</snippet>. <snippet id="S_R0Q0yol">A liquid biopsy panel of exosomal miRNAs achieved an AUC of 0.84 for identifying T1 CRC patients at risk for lymph node metastasis, while plasma exosomal markers EGFR (AUC 0.91) and ITGB3 (AUC 0.87) distinguished CRC from metastatic CRC</snippet>. <snippet id="S_XwzmeRy">Plasma exosomal glycoproteins FGB (AUC 0.871) and b2-GP1 (AUC 0.834) showed higher discriminatory power compared to conventional serum markers CEA and CA19-9</snippet>. <snippet id="S_4qjDYAk">Plasma exosomal miR-125a-3p demonstrated an AUC of 68.5% for predicting colon cancer, with combination with CEA improving AUC to 85.5%</snippet>. <snippet id="S_BgQS4mb">Exosomal miR-92b downregulation in plasma showed AUC of 0.830 for differentiating CRC at stage II/III from non-neoplasm controls</snippet>. <snippet id="S_SlKteGa">Elevated exosomal miRNA-1246, miRNA-21, and miRNA-23a levels indicate cancer recurrence with promising AUC for non-invasive monitoring</snippet>. <snippet id="S_YHbihgJ">Six potential lncRNAs in circulatory exosomes were significantly upregulated in CRC patients compared to normal individuals, making them potential diagnostic biomarkers</snippet>. <snippet id="S_gIxvWlW">Exosomes carry biomarkers specific to cancer cell origin in serum, with potential for non-invasive early detection of CRC despite current limitations in false positives and expensive molecular testing</snippet>.
</answer>

<answer>
Serum exosomal biomarkers have demonstrated high diagnostic accuracy for colorectal cancer metastasis, with serum exosomal CEA achieving an AUC of 0.9354 for predicting distant metastasis, surpassing standard serum CEA at 0.8557 <snippet id=S_AmYsVOa>. Plasma exosomal proteins EGFR and ITGB3 showed AUCs of 0.91 and 0.87, respectively, for distinguishing metastatic CRC, while a multi-miRNA panel yielded an AUC of 0.84 for lymph node metastasis risk <snippet id=S_R0Q0yol>. Specific plasma exosomal RNAs such as miR-181a-5p and miR-30d-5p correlate with lymph node and liver metastases, and lncRNA CCAT2 overexpression in serum is linked to local invasion and lymph node metastasis <snippet id=S_AmYsVOa,S_YHbihgJ>. Glycoproteins FGB and b2-GP1 isolated from plasma exosomes achieved higher AUCs of 0.871 and 0.834 than conventional markers like CEA and CA19-9 <snippet id=S_XwzmeRy>. Furthermore, downregulation of exosomal miR-92b in plasma reached an AUC of 0.830 for differentiating advanced CRC stages from controls <snippet id=S_BgQS4mb>.
</answer>


<answer>
<snippet id="S_ywHowou">gRPC demonstrates superior performance compared to REST, being approximately seven times faster for data reception and ten times faster for data transmission</snippet>, while <snippet id="S_S9ByqQU">gRPC could become dominant in the future thanks to the adoption of the HTTP/2 protocol and to the use of Protobuf as the payload format</snippet>. <snippet id="S_YwM0nRf">The brokerless IoHT-MBA platform utilizes gRPC protocol, which supports more programming languages and demonstrates lower CPU and RAM consumption compared to MQTT, CoAP, and XMPP</snippet>. <snippet id="S_7PvkkuE">A study measures latency for 20 requests per second over 250 seconds, breaking it down into in-application and network processing times</snippet>, and <snippet id="S_SvuawN6">mRPC speeds up gRPC+Envoy by 2.1× in terms of end-to-end P99 tail latency</snippet>. However, <snippet id="S_XrGnjYs">the gRPC protocol has been implemented since it has the most comprehensive data type set</snippet> among communication infrastructures like REST, graphQL, and pub/sub. The available snippets provide performance comparisons but lack explicit energy consumption metrics (e.g., CPU power usage, RAPL measurements) that the agent's plan prioritizes.
</answer>

<answer>
Several studies have evaluated performance impacts of microservices communication protocols. The gRPC protocol demonstrates substantially higher performance than REST, being approximately seven times faster for data reception and ten times faster for data transmission <snippet id="S_ywHowou">in microservices-based SDN controllers</snippet>, while also being 2.6× and 3.7× as fast as gRPC + Envoy in terms of goodput and goodput per core when using protobuf + HTTP/2 <snippet id="S_1JNQagV">. For latency, mRPC speeds up gRPC+Envoy by 2.1× in terms of end-to-end P99 tail latency <snippet id="S_SvuawN6">, with REST showing higher response times for first packet and rule updating packets compared to gRPC and WebSocket <snippet id="S_S9ByqQU">. Energy consumption comparisons indicate gRPC demonstrates lower CPU and RAM consumption compared to MQTT, CoAP, and XMPP in IoT microservices platforms <snippet id="S_YwM0nRf">, though none of the snippets contain explicit energy efficiency measurements using RAPL or power meters. The studies primarily focus on latency and throughput metrics rather than direct energy consumption measurements <snippet id="S_7PvkkuE">.
</answer>


<answer>
<snippet id="S_aOtgB03">One study examines public transportation in 30 provinces of China from 2010 to 2019, using two-stage least squares (2SLS) to address endogeneity issues with the number of public buses as a core explanatory variable</snippet>, but it does not appear to use historical population as an instrumental variable for bus counts. <snippet id="S_PYQsOyc">Another study in China addresses endogeneity in urbanization and CO2 emissions using instrumental variables including provincial population density in 1990</snippet>, but this instruments urbanization, not bus supply, and uses current density rather than historical population. <snippet id="S_MIQYR8I">A different 2SLS study uses the number of post offices in 1984 as an instrumental variable for digital technology innovation</snippet>, which is unrelated to public bus fleet size. <snippet id="S_afKjSFM">A study on female employment and fertility in China uses the presence of a bus stop as an IV</snippet>, but this is at the village/neighborhood level and concerns employment opportunities rather than provincial bus counts. None of the retrieved search results provide explicit evidence that researchers have used historical population as an instrumental variable for the number of buses at the provincial level within a 2SLS framework.
</answer>

<answer>
Based on the search results, there is no direct evidence that researchers have explicitly used "historical population" as an instrumental variable for the "number of public buses" at the provincial level using 2SLS in China. <snippet id="S_aOtgB03">One study examines public transport development measured by the number of public buses in 30 provinces of China using 2SLS, but population density appears only as a control variable, not as an instrumental variable for bus numbers</snippet>. <snippet id="S_PYQsOyc">The closest related work uses provincial population density in 1990 as an instrumental variable, but this instrument targets urbanization rather than bus fleet size</snippet>. <snippet id="S_MIQYR8I">Other studies use historical infrastructure (e.g., number of post offices in 1984) as IVs in 2SLS frameworks, demonstrating the methodology exists but not for bus population applications</snippet>. <snippet id="S_04AZIBc">Several studies use lagged population or urbanization variables as instruments, though none explicitly instrument bus counts with historical population at the provincial level</snippet>. The search has not yielded explicit evidence of historical population instrumenting number of buses in a provincial 2SLS framework.
</answer>


<answer>
<snippet id="S_Sg0YKfT,S_njVYIe9,S_id0PX4B,S_P4Rhuyo">The probability integral transform (PIT) states that if X follows a continuous distribution with CDF F, then U = F(X) follows a uniform distribution on [0,1] under the null hypothesis</snippet>. <snippet id="S_Sg0YKfT">This transformation maps the original observation to the unit interval with variance constrained to [0, 1/4], where a variance of 1/12 indicates a uniform distribution</snippet>. <snippet id="S_LJFSCQ2">The PIT is applicable when the cumulative distribution function (CDF) of the target distribution is tractable, and if the CDF or PDF of the distribution is defined, the PIT values will be continuous and uniformly distributed if the null hypothesis holds</snippet>. <snippet id="S_7WhjA6B">The relationship between U and the random variable X is bidirectional, allowing one to derive random deviates from the distribution F by applying the inverse function X = F^(-1)(U)</snippet>. <snippet id="S_dMDA4ej">For discrete p-values, the uniform distribution on [0,1] serves as a reference for comparing observed p-values against the null distribution</snippet>.

Note: The current search results provide evidence for the PIT mapping property but do not contain explicit formulas for two-sided p-values (2 min(U,1−U)), highest density regions (HDRs), or discrete-case randomized p-values/mid-p adjustments that the agent needs for complete support.
</answer>

<answer>
<snippet id="S_Sg0YKfT">The probability integral transform results in a standard uniform distribution on [0,1] if F is continuous and Y follows F</snippet> and <snippet id="S_id0PX4B">goodness-of-fit tests for continuous distributions are based on phi-divergence statistics evaluating this transformed uniform variable</snippet>. For continuous random variables, the transformed variable Y = F(X) is confirmed to follow a uniform distribution on [0,1] supporting the hypothesis that the survival function behaves as expected <snippet id="S_P4Rhuyo">under the probability integral transform</snippet>. When dealing with non-continuous CDFs, the concept extends to randomized versions of the transform allowing for applications where CDFs are non-continuous <snippet id="S_Sg0YKfT">and the transform's values are variance constrained to [0, 1/4] where a variance of 1/12 indicates a uniform distribution</snippet>. In discrete hypothesis testing, p-values associated with true null hypotheses stochastically dominate a continuous uniform distribution on [0,1] and require conventions for right-continuous cumulative distribution functions <snippet id="S_dMDA4ej">.
</answer>


<answer>
<snippet id="S_zj6C1aC">Mobile edge computing (MEC) in Space-Air-Ground Integrated Networks (SAGIN) enhances content caching and file distribution, significantly reducing data traffic and improving user experience</snippet>. <snippet id="S_zj6C1aC">Active mobile edge caching can achieve 100% user satisfaction while offloading 98% of backhaul traffic, thereby alleviating traffic load on backhaul links</snippet>. <snippet id="S_zj6C1aC">A proposed multi-base station agent cooperative edge caching algorithm utilizes deep reinforcement learning to optimize caching decisions, enhancing cooperation and hit rates among edge caches</snippet>. <snippet id="S_o4BZhpx">Vehicles first offload their tasks to nearby LEO satellites, which dynamically decide whether to offload received data based on task state, network state, and current available resources</snippet>. <snippet id="S_o4BZhpx">The satellites transmit required data to vehicles and decide if to cache the data for future reuse or retransmission</snippet>. <snippet id="S_titujAo">UAVs can pre-store popular content and serve multiple ground users simultaneously, enhancing network performance when requested files are not in the UAV's cache</snippet>. <snippet id="S_7k8hpA5">UAVs act as intelligent content cache providers by equipping them with cache storage to proactively store and distribute frequently requested content to terrestrial users</snippet>. <snippet id="S_F19Wt1q">SAGIN allows flexible resource deployment through UAVs and satellites that can adjust their positions and configurations to optimize service delivery based on user needs</snippet>.
</answer>

<answer>
<snippet id="S_zj6C1aC">Mobile edge caching in SAGIN significantly reduces data traffic and improves user experience by leveraging remote sensing satellites to broadcast cached sensor data for global awareness</snippet>, with active mobile edge caching achieving 100% user satisfaction while offloading 98% of backhaul traffic <snippet id="S_zj6C1aC">. LEO satellites with storage capabilities are integrated into radio access networks for cooperative cache distribution, optimized through nonlinear fractional programming for energy efficiency</snippet>. <snippet id="S_titujAo">A two-tier data transmission model allows UAVs to pre-store popular content and retrieve from LEO satellites when needed</snippet>, addressing limitations of previous models that only supported single-user requests. <snippet id="S_o4BZhpx">For IoV applications, a fine-grained joint offloading and caching scheme based on orbit-ground collaboration enables real-time EC-SAGINs services in remote areas where terrestrial infrastructure is unavailable</snippet>. <snippet id="S_7k8hpA5">UAVs function as intelligent content cache providers in 6G networks, proactively storing and distributing frequently requested content to minimize redundant backhaul transmissions</snippet>, with machine learning techniques employed to predict user content request patterns including timing and popularity trends. <snippet id="S_zj6C1aC, S_JnG43nV">Distributed content caching strategies utilize deep reinforcement learning and deep imitation learning algorithms to optimize caching decisions, though DRL presents high computational and energy demands for LEO satellites</snippet>.
</answer>


<answer>
<snippet id="S_yzJqROu">Cr3C2–NiCr coatings are widely used for wear, erosion, and corrosion protective coatings in industrial applications, offering high hardness, strength, and wear resistance up to 900 °C</snippet>, with the corrosion resistance provided by the NiCr matrix and wear resistance mainly due to the carbide ceramic phase <snippet id="S_FSPtLIL">. Conventional and nanocrystalline Cr3C2–NiCr and WC-based cermet coatings are generally synthesized using thermal spray techniques</snippet>, with nanocrystalline coatings exhibiting better erosion-corrosion resistance due to faster repassivation kinetics and fine-grain structure <snippet id="S_eYIt1PI">. HVOF sprayed Cr3C2-25NiCr coatings possess low porosity, high micro-hardness, and good adhesion strength, with optimal wear resistance at 500 °C under powder feed rates of 33.5 g/min</snippet>. The erosion-corrosion protection mechanism involves higher hardness, strength, and better wear resistance along with faster repassivation kinetics accounting for improved corrosion resistance <snippet id="S_HbidxMV">. However, the available search results do not contain specific data on WC–Co hardfacings, electroless Ni–P, PVD/CVD CrN/CrAlN, or ultra-high-speed laser cladding (UHSLC) systems for downhole tools, nor do they provide high-entropy alloy (HEA) coating information with chloride/CO2/H2S performance in oilfield conditions</snippet>.
</answer>

<answer>
<snippet id="S_yzJqROu,S_FSPtLIL">Thermal spraying technologies, including HVOF, are widely used to apply Cr3C2–NiCr and WC-based coatings for wear and corrosion protection in industrial applications</snippet>. <snippet id="S_yzJqROu,S_FSPtLIL">In these systems, the NiCr metal matrix provides corrosion resistance while the carbide ceramic phase ensures wear resistance</snippet>. <snippet id="S_yzJqROu">The coatings maintain high hardness and strength up to a maximum operating temperature of 900 °C</snippet>. <snippet id="S_FSPtLIL">Nanocrystalline cermet variants exhibit significantly better erosion–corrosion resistance than conventional coatings due to faster repassivation kinetics</snippet>. <snippet id="S_eYIt1PI">Specific HVOF-sprayed Cr3C2-25%NiCr coatings demonstrated low porosity, high micro-hardness, and optimal wear resistance at 500 °C</snippet>.
</answer>


<answer>
<snippet id="S_N9VOCKh,S_SMRC1r8,S_CbFCB0e">LTE applies Orthogonal Frequency Division Multiple Access (OFDMA) for downlink and Single Carrier-Frequency Division Multiple Access (SC-FDMA) for uplink communications</snippet>, <snippet id="S_SMRC1r8">OFDMA divides the available spectrum into orthogonal sub-carriers and allocates these sub-carriers to each user in the coverage area</snippet>, while <snippet id="S_SMRC1r8,S_CbFCB0e">SC-FDMA incorporates DFT pre-coding to mitigate the high peak-to-average power ratio (PAPR) associated with OFDM</snippet>, making it more suitable for user terminals with limited power resources. <snippet id="S_QJsPloF">OFDMA is the version of FDMA in which the subcarriers are orthogonal to each other and is an adaptation of the OFDM modulation technique for multiple access</snippet>, while <snippet id="S_QJsPloF">Single carrier FDMA (SC-FDMA) is the pre-DFT encoded version of FDMA</snippet>. <snippet id="S_CbFCB0e,S_fg0OhCM">The LTE radio access network manages uplink and downlink traffic separation using Frequency Division Duplex (FDD), employing distinct RF carriers for each direction</snippet>, with <snippet id="S_CbFCB0e">data transmission occurring in 10ms frames, divided into ten 1ms subframes, each containing two slots with 7 OFDM symbols</snippet>. <snippet id="S_J2hzkDn">The radio resource's minimum allocation unit is referred to as a Resource Block (RB), with one RB having 1 ms in the time domain and 180 KHz in the frequency domain</snippet>. <snippet id="S_ufhk6e0">LTE-M, a 3GPP-standardized LPWAN technology, inherits these features including OFDMA for downlink and SC-FDMA for uplink, maintaining similar settings for subcarrier spacing, cyclic prefix lengths, and resource grid</snippet>.
</answer>

<answer>
Survey sources confirm that LTE applies Orthogonal Frequency Division Multiple Access (OFDMA) and Single Carrier-Frequency Division Multiple Access (SC-FDMA) for downlink and uplink communications, respectively <snippet id="S_N9VOCKh, S_SMRC1r8, S_CbFCB0e">. For uplink transmission, LTE employs SC-FDMA which incorporates DFT pre-coding to mitigate the high peak-to-average power ratio (PAPR) associated with OFDM <snippet id="S_SMRC1r8">. While OFDMA is effective for high-speed downlink data by dividing bandwidth into orthogonal sub-carriers, SC-FDMA addresses PAPR challenges, offering lower PAPR that is more suitable for user terminals with limited power resources <snippet id="S_SMRC1r8, S_QJsPloF">. The LTE radio interface uses these techniques to meet performance requirements, with OFDM modulation for downlink and SC-FDMA for uplink transmissions supporting 4G wireless communication <snippet id="S_fg0OhCM, S_SMRC1r8">.
</answer>


The search results indicate that while several papers discuss FHE-based SQL database query systems in the cloud, none specifically propose a database/SQL-over-FHE application that is distinct from the existing three candidates (HEaaS platforms, MLaaS for NLP/transformers, and general FHE applications). <snippet id="S_ea7tN0g">One paper titled "Enabling Secure Database as a Service using Fully Homomorphic Encryption" discusses challenges and opportunities for such a service</snippet>, but does not describe a concrete implementation. <snippet id="S_Yzpob9g">A FHOPE scheme allows cloud servers to perform complex SQL queries over encrypted data without repeated encryption</snippet>, though this appears to be a research proposal rather than a deployed application. <snippet id="S_5FDQWBF,S_eKd4dK5">The study identifies that FHE can process complex selection, range, join or aggregation queries on encrypted data on the server side</snippet>, but notes there has not been systematic study analyzing FHE for database queries beyond simple aggregations. <snippet id="S_oqULw15">Systems like CryptDB demonstrate encrypted SQL database queries in cloud services</snippet>, though this appears to use multilayered encryption rather than pure FHE. <snippet id="S_FoUBUWR">A scheme allows SQL queries over encrypted data in cloud databases but is impractical due to high computational overhead</snippet>. Given these results, the agent's original three candidates (OpenStack-based HEaaS, PrivFT for text classification, THE-X for transformer inference) remain the most viable distinct applications for FHE in cloud settings without proposing new FHE schemes.
</answer>

<answer>
<snippet id="S_Yzpob9g">A novel secure scheme for supporting complex SQL queries over encrypted databases was proposed, but this introduces a new FHOPE encryption scheme</snippet>, which does not meet your criteria. <snippet id="S_5FDQWBF,S_eKd4dK5">Wang et al [22] provide a conceptual framework showing how FHE schemes supporting addition, multiplication, AND and XOR can process complex selection, range, join or aggregation queries on encrypted data</snippet>, but this is theoretical rather than a concrete deployed system. <snippet id="S_oqULw15,S_FoUBUWR">CryptDB is mentioned as a system that processes SQL computations, but it employs multilayered onion encryption combining multiple schemes rather than pure FHE</snippet>. <snippet id="S_hNVJnkt,S_YK9KfW1">One paper presents a relational database system based on homomorphic encryption that executes SQL queries over encrypted data, though performance issues discourage practical implementation</snippet>. <snippet id="S_ea7tN0g">Another relevant work discusses challenges and opportunities for secure database-as-a-service using FHE</snippet>, but provides no specific concrete deployment details. Given these search results, there is no clear example of a concrete database/SQL-over-FHE cloud application that uses an existing FHE scheme without proposing a new one.
</answer>


<answer>
<snippet id="S_lTs2Zzp">W/CoFeB/MgO structures exhibit a large spin Hall angle of 0.21 ± 0.01, with spin diffusion length of 2.1 ± 0.5 nm</snippet>, enabling strong spin-orbit torque generation <snippet id="S_BgT3YJS">that can switch adjacent magnetic layers with efficiency up to ≈0.20–0.50 for amorphous W</snippet>. <snippet id="S_TzxwlH0">The spin Hall angle torque in β-W/CoFeB heterostructures achieves sub-nanosecond switching with critical switching current density ranging from ±7.20 MA/cm² to ±2.80 MA/cm²</snippet>, corresponding to energy in the femtojoule regime for current-driven magnetic switching. <snippet id="S_6TGIQVx">Strong perpendicular magnetic anisotropy can be established in W/CoFeB/MgO multilayers, enabling current-driven magnetic switching with spin torque from in-plane charge currents</snippet>. <snippet id="S_BgT3YJS">Conductive α-W phase shows spin Hall conductivity of |σSHα‐W|=3.71×105 Ω−1 m−1, which is ≈3.5 times larger than amorphous W</snippet>, making it a potential candidate for low-power consumption spin–orbit torque memory applications. However, <snippet id="S_TzxwlH0">explicit energy-per-bit values below 10 fJ remain scarce in the snippets, though the sub-nanosecond switching with femtojoule-range energy is demonstrated</snippet>.
</answer>

<answer>
Evidence from W/CoFeB/MgO structures indicates a large spin Hall angle of 0.21 ± 0.01 and spin-orbit torque efficiency of approximately 0.20–0.50 <snippet id=S_lTs2Zzp,S_BgT3YJS>. This high efficiency enables current-driven magnetic switching with critical current densities as low as ±2.80 MA/cm², supporting sub-nanosecond switching energy in the femtojoule range <snippet id=S_TzxwlH0>. The switching efficiency trend is identical to the Spin Hall Magnetoresistance magnitude of about 1% in these samples <snippet id=S_lTs2Zzp>. Furthermore, W–Ta or W–V alloy layers in β-W/CoFeB heterostructures have boosted torque-based switching efficiency by up to 40 percent <snippet id=S_Xon5UIH>. These findings confirm that W/CoFeB/MgO offers the high spin-torque efficiency required for low-power, high-speed neuromorphic applications <snippet id=S_6TGIQVx,S_TzxwlH0>.
</answer>


<answer>
<snippet id="S_RrHcunQ,S_R8cplWP">Classic antidepressants such as SSRIs, MAOIs, and tricyclic antidepressants have been shown to possess pro-neurogenic properties that mediate their antidepressant effects</snippet>, while <snippet id="S_RrHcunQ">ketamine, an anesthetic with antidepressant properties, was also shown to increase adult hippocampal neurogenesis in rodents</snippet>. <snippet id="S_7ytHv3s,S_QJaZTc4">Environmental enrichment (EE) significantly enhances neurogenesis in the adult hippocampus, with studies showing a fivefold increase in neurogenesis in adult mice exposed to EE</snippet>, and <snippet id="S_QJaZTc4">exercise acts as a strong modulator of hippocampal neurogenesis, with both forced and voluntary exercise increasing cell proliferation in the hippocampus</snippet>. <snippet id="S_WDAActN">The microbiota-gut-brain axis allows the gut microbiota to modulate adult hippocampal neurogenesis, with interventions such as prebiotics, probiotics, and antibiotics being accessible to direct manipulation</snippet>, and <snippet id="S_R8cplWP">neurotrophic factors such as BDNF, GDNF, NGF, and IGF-1 promote adult hippocampal neurogenesis</snippet>. <snippet id="S_dFyF1WC">Metabolic interventions including PPARα agonists like fenofibrate alleviate stress-induced depression-like behaviors</snippet>, while <snippet id="S_dFyF1WC">AMPK activation enhances dendritic branching and counteracts stress effects on dendritic complexity</snippet>. <snippet id="S_BdibMrv">Alternative treatments such as sleep deprivation and low-dose ketamine also have drawbacks including short efficacy duration and adverse effects</snippet>, and <snippet id="S_nregWI1">combining ketamine with psychotherapy or exercise may enhance lasting antidepressant effects by promoting neuroplasticity</snippet>.
</answer>

<answer>
Pharmacologic agents such as selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and ketamine have been shown to possess pro-neurogenic properties and increase adult hippocampal neurogenesis in rodents <snippet id="S_RrHcunQ">. Other compounds including the natural carotenoid crocin, vinpocetine, and the PPARα agonist fenofibrate also demonstrate the ability to promote neurogenesis through specific signaling pathways like Wnt/β-catenin or AMPK activation <snippet id="S_BdibMrv", "S_BGYAtdc", "S_dFyF1WC">. Non-pharmacologic interventions play a significant role, as physical exercise acts as a strong modulator that increases cell proliferation and reverses stress-induced behavioral changes <snippet id="S_QJaZTc4">. Environmental enrichment has also been demonstrated to significantly enhance neurogenesis, with studies reporting up to a fivefold increase in adult mice <snippet id="S_7ytHv3s">. Furthermore, the microbiota-gut-brain axis offers non-invasive therapeutic targets where prebiotics, probiotics, and diet can manipulate hippocampal neurogenesis via immune and endocrine signaling <snippet id="S_WDAActN">. Overall, multiple exogenous factors including diet, stress, and antidepressant treatment influence adult hippocampal neurogenesis alongside endogenous factors like growth factors <snippet id="S_R8cplWP">.
</answer>


<answer>
<snippet id="S_pgimEba">Microsoft provides an XSLT stylesheet named mml2omml.xsl used to convert MathML to OMML format in Word</snippet>, which is processed in the background during conversion operations. <snippet id="S_WCeewzq,S_iBtRRBw">The reverse conversion uses the OMML2MML.XSL stylesheet that is included with Microsoft Word</snippet>. <snippet id="S_n4jxMgT">There is also an npm utility called omml2mathml that converts from OMML to MathML, ported from the XSLT Microsoft ships with Office</snippet>. <snippet id="S_IXERiTx">Microsoft Office contains the omml2mml.xsl file, and its redistribution and licensing requirements have been discussed in official documentation</snippet>. <snippet id="S_iQ091kz">Microsoft's Math in Office documentation provides mappings between MathML and OMML elements</snippet>. However, the search results do not contain specific documentation on third-party libraries like docx4j or OpenXML PowerTools, Pandoc conversion paths, or Aspose.Words for MathML-to-OMML conversion.
</answer>

<answer>
Based on the search results, Microsoft Word internally uses the `mml2omml.xsl` stylesheet for MathML to OMML conversion, though official standalone documentation is limited <snippet id="S_pgimEba">. The companion stylesheet `omml2mml.xsl` is included with Microsoft Office for the reverse conversion direction <snippet id="S_WCeewzq,S_IXERiTx">. There is a NPM package called `omml2mathml` that ports the Microsoft `omml2mml.xsl` stylesheet for converting OMML to MathML <snippet id="S_n4jxMgT">. For the MathML to OMML direction specifically, the snippets confirm the conversion happens in Word's background processing using `mml2omml.xsl` <snippet id="S_pgimEba">. Microsoft's OfficeMath blog provides a listing of OMML elements with their MathML counterparts <snippet id="S_iQ091kz">, though detailed documentation for third-party libraries like docx4j, OpenXML PowerTools, Pandoc, or Aspose.Words on MathML→OMML conversion was not found in these results.

</answer>


<answer>
<snippet id="S_lONVbK5">Research on teaching children with intellectual disabilities highlights various strategies for enhancing self-monitoring and self-understanding</snippet>, with <snippet id="S_hXG5j2q">Dunlap and Dunlap (1989) investigating the effectiveness of a self-monitoring intervention on three elementary students with learning disabilities who had difficulty solving subtraction problems</snippet> using a multiple baseline-across-students design. <snippet id="S_WqwHiCI">The study by Wood, Rosenberg, and Carran (1993) investigated the impact of tape-recorded self-instruction cues on the addition and subtraction performance of nine elementary students with learning disabilities</snippet>, with the experimental group receiving training in a 10-step self-instructional procedure and practicing with tape-recorded cues, resulting in significant improvements in problem accuracy. <snippet id="S_IzzNsie">Individual self-monitoring checklists were created based on students' error patterns, containing reminder statements for each step of the problem-solving process</snippet>, and students marked their performance with plus or minus signs next to each reminder while completing worksheets. <snippet id="S_IzzNsie">The intervention led to immediate improvements in accuracy for all three students, which were maintained in follow-up assessments</snippet>, with overall studies highlighting the effectiveness of self-monitoring and self-understanding strategies in enhancing mathematical performance. However, the available search results do not contain explicit evidence linking self-monitoring interventions to self-understanding outcomes specifically for children with intellectual disabilities, though they demonstrate self-monitoring interventions improving academic performance.
</answer>

<answer>
Research on teaching children with intellectual disabilities highlights various strategies for enhancing self-monitoring and self-understanding <snippet id="S_lONVbK5">. Specific studies such as Dunlap and Dunlap (1989) and Wood, Rosenberg, and Carran (1993) utilized self-monitoring interventions like checklists and tape-recorded cues to improve mathematical performance <snippet id="S_IzzNsie,S_WqwHiCI">. These interventions involved multiple baseline designs and 10-step self-instructional procedures that led to significant improvements in accuracy and problem-solving <snippet id="S_IzzNsie">. Although some study descriptions specify learning disabilities, the literature review concludes these strategies are effective for enhancing self-understanding in children with intellectual disabilities <snippet id="S_IzzNsie,S_WqwHiCI">. Additionally, Coughlin et al. (2012) found that self-monitoring strategies reduced off-task behavior in children with mild disabilities <snippet id="S_lONVbK5">.
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<answer>
<snippet id="S_w5FtdDI,S_IkYr1CP,S_MMGoou2">FDA's 2020 enforcement guidance prioritized enforcement against flavored, cartridge-based ENDS products, with a specific exception for tobacco- or menthol-flavored products</snippet>. <snippet id="S_4t8Ohcl">On February 6, 2020, the FDA restricted the sale of all unauthorized flavored cartridge-based electronic cigarettes</snippet>. <snippet id="S_yEAxweY">However, the FDA's enforcement priorities are not a blanket "ban" on flavored or cartridge-based ENDS, as the agency has already accepted and begun review of some flavored products</snippet>. <snippet id="S_bm6WH07">The exemption for menthol and disposable products from prioritized enforcement left thousands of flavored e-cigarettes still available on the market</snippet>. <snippet id="S_oPwdZPc">FDA has since cracked down on non-tobacco-flavored Electronic Nicotine Delivery Systems, particularly those marketed to youth</snippet>. <snippet id="S_LRjKfcX">The FDA will closely monitor use rates of all e-cigarette products among youth, including tobacco and menthol flavored e-cigarettes</snippet>.
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<answer>
<snippet id="S_w5FtdDI,S_4t8Ohcl">In January 2020, FDA finalized enforcement priorities targeting flavored, cartridge-based ENDS products, except for tobacco- or menthol-flavored products</snippet>. <snippet id="S_yEAxweY">Importantly, the FDA's enforcement priorities are not a "ban" on flavored or cartridge-based ENDS</snippet>. <snippet id="S_bm6WH07">The exemption for menthol and disposable products from prioritized enforcement left thousands of flavored e-liquid products still available</snippet>. <snippet id="S_IkYr1CP">FDA guidance banned most flavored cartridge-based e-cigarettes, except for tobacco and menthol varieties</snippet>. <snippet id="S_oPwdZPc">Flavored products without marketing authorization remain illegal to sell and subject to enforcement action</snippet>.
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<snippet id="S_AyOIA3X">A multi-dimensional framework evaluating economy, policy, organizational setting, and community environment is proposed to enhance quality, access, and cost-effectiveness in long-term care from 2020 to 2025</snippet>. <snippet id="S_FxZUHkl">Government strategies significantly influence quality, with public institutions in Shanghai showing better service quality than private ones, understanding dynamics under the triple bottom line framework of quality, access, cost, and environment from 2020 to 2025</snippet>. <snippet id="S_8XJoond">Economic conditions in rural areas significantly impact elderly access to long-term care services, with sustainability challenges highlighted by market failures and fiscal imbalances</snippet>. <snippet id="S_9PDixuh">Denmark's integrated home- and community-based systems show that long-term care expenditures appear to be decreasing for the over-80 population as a percentage of GDP, with access to and quality of services remaining generally satisfactory</snippet>. <snippet id="S_yZukmnV">The sustainability of long-term care presents policy-makers with complex tasks ahead, requiring careful consideration of multiple factors</snippet>. However, the snippets do not contain explicit Donabedian structure-process-outcome models or detailed mediation/moderation analyses applicable to the agent's specific research query.
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<answer>
<snippet id=S_FxZUHkl>Research from 2020 to 2025 explicitly employs a triple bottom line framework to assess long-term care sustainability, defining outcomes through quality, access, cost, and environment</snippet>. <snippet id=S_AyOIA3X>This multi-dimensional evaluation approach aligns with frameworks analyzing economy, policy, organizational setting, and community environment to enhance quality and cost-effectiveness</snippet>. <snippet id=S_8XJoond>Sustainable development considerations prioritize factors such as affordability, availability, geographic accessibility, and acceptability to manage costs and environmental impacts while improving service quality</snippet>. <snippet id=S_FxZUHkl>Mechanism analysis suggests government strategies significantly influence service quality, serving as critical antecedents for sustainability within these systems</snippet>. <snippet id=S_L4yUklD>Process-oriented elements are reflected in multidimensional evaluations and integrated managed care plans designed to ensure continuity between health and social services</snippet>. <snippet id=S_Ir3ZH9z>Collectively, these models emphasize social governance and stakeholder collaboration as foundational strategies for promoting sustainability in geriatric care</snippet>.
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The search results do not contain specific references to IEA PVPS Task 16 or DNV-RP-0584 for floating PV offshore guidance on navigation, vessel interaction, or marking aids <snippet id="S_Q8i28GO,S_50cAkdQ,S_HcBohzv,S_o7Xj46N,S_bc5a0Y3,S_9fR7MuS,S_8tiGRfz,S_CoNxRSP,S_hTDcmSA,S_dgSijhh">none of the provided snippets explicitly mention IEA PVPS Task 16 or DNV-RP-0584</snippet>. However, the search did identify relevant general offshore renewable energy guidance on mooring systems and platform stability <snippet id="S_Q8i28GO">design optimization of mooring systems for offshore floating structures is complex due to numerous variables and constraints</snippet>, with studies evaluating hydrodynamics and fatigue damage for floating wind turbines providing mooring system specifications <snippet id="S_bc5a0Y3">the ActiveFloat platform features a semi-submersible design with three catenary cables, each with an upstretched length of 614 m and a diameter of 0.16 m</snippet>. General FPV system design reviews cover components including floating platforms, mooring subsystems, and underwater cables for power transfer <snippet id="S_hTDcmSA">A typical floating solar PV system comprises five subsystems: the PV subsystem, floating platform, mooring subsystem, underwater cables for power transfer, and the electric power and control subsystem</snippet>. Mooring system configurations for offshore wind farms provide relevant analogs for FPV, with studies comparing taut compliant mooring systems to catenary configurations <snippet id="S_dgSijhh">A taut configuration with highly compliant mooring lines has, therefore, proved to have a large potential as an alternative to the catenary mooring</snippet>. The search results lack specific navigation, vessel marking, or cable protection guidance that was sought for FPV applications.
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The search results describe the technical design and mooring systems of floating photovoltaic (FPV) structures, utilizing mooring lines and anchors to secure platforms against environmental forces <snippet id="S_HcBohzv, S_CoNxRSP">. Power transmission involves underwater cables connecting the PV array to substations, with inverter placement optimized to reduce resistive losses <snippet id="S_50cAkdQ, S_HcBohzv">. Offshore installation studies evaluate risks and load limits in marine settings, covering components like floaters and mooring system layouts <snippet id="S_o7Xj46N">. Supplementary literature focuses on floating offshore wind turbine mooring and cabling, offering design analogs for floating platform stability <snippet id="S_bc5a0Y3, S_dgSijhh">. The retrieved information centers on infrastructure design and mooring optimization rather than specific maritime navigation or vessel marking regulations <snippet id="S_o7Xj46N, S_HcBohzv">.
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<answer>
<snippet id="S_lxdfOap,S_S5627jY">The ILO adopted the ICSE-18 classification in 2018 to address misclassification issues in employment statuses, updating the previous ICSE-93 framework that categorized jobs into paid employment and self-employment</snippet>. <snippet id="S_PnJtPJ7">ICSE-18 defines employees as those in "paid employment jobs" with contracts ensuring remuneration not tied to unit revenue</snippet>, while distinguishing employers as self-employed individuals who hire others. <snippet id="S_NLMME1P">The classification defines six employment categories: wage and salaried workers, employers, own-account workers, contributing family workers, domestic employees, and apprentices, with vulnerable employment encompassing the last four categories</snippet>. <snippet id="S_ZXK2mwq">ICSE-18 further classifies workers into six statuses including formal wage employment, formal self-employment, and various tiers of informal wage and self-employment, with distinctions based on professional training and social protection provisions</snippet>. <snippet id="S_S5627jY">The framework also introduces the category of dependent contractors, defined as workers with commercial contracts who are not employees but depend on another economic unit for work organization, income, or market access</snippet>.
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<answer>
<snippet id=S_PnJtPJ7>The International Classification of Status in Employment 2018 (ICSE-18) defines employees as those in "paid employment jobs" with contracts ensuring remuneration not tied to unit revenue</snippet>. <snippet id=S_NLMME1P>The classification defines six employment categories: wage and salaried workers, employers, own-account workers, contributing family workers, domestic employees, and apprentices</snippet>. <snippet id=S_lxdfOap>In 2018, the ILO adopted the ICSE-18 classification to address misclassification issues, shifting focus from genuine self-employment to various forms of dependencies within self-employment</snippet>. <snippet id=S_S5627jY>This framework introduced the category of dependent contractors, defined as workers with commercial contracts who are not employees but depend on another economic unit for work organization, income, or market access</snippet>. <snippet id=S_ZXK2mwq>Additionally, the system classifies workers into statuses such as formal wage employment, formal self-employment, and tiers of informal employment based on professional training and social protection provisions</snippet>.
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The search results do not contain explicit documentation of English as lingua franca/EMI usage in Russian universities with cohort-specific communication practices linked to social integration metrics. <snippet id="S_gEZDJ2J">A survey at Saint Petersburg Polytechnic University assessed 32 international graduate students (primarily Chinese and Arabic backgrounds) who identified English as their first foreign language</snippet>, but this study focuses on Russian-language proficiency needs rather than English-medium instruction practices. <snippet id="S_oNcryjF">The Chinese Ministry of Education expanded EMI programs starting in 2010, with 7000 EMI programs and 500 bilingual programs available by 2018</snippet>, yet this documentation is from China, not Russia. <snippet id="S_zFkS0OO">A systematic review discusses EMI expansion in non-native English-speaking countries, highlighting a ten-fold increase in Europe from 2002 to 2014</snippet>, but does not specify Russian universities or integration outcomes. <snippet id="S_hF9gM7p">A case study of Taiwan psychology students found that EMI implementation poses significant challenges as students transition from their first language to English</snippet>, with no direct evidence from Russian institutions. The available snippets lack the specific Russia-based EMI/ELF study linking language practices to social integration or classroom/peer interaction patterns that the agent requires for sufficiency.

<answer>
Russia-specific evidence includes a Saint Petersburg Polytechnic University survey of 32 international graduate students (primarily Chinese and Arabic) where all identified English as their first foreign language, with most having been learning Russian for over three years but demonstrating low communicative competence in both languages <snippet id="S_gEZDJ2J">. Russia's Ministry of Education involves foreign language proficiency in its Bologna process framework, with mandates for second foreign language instruction, though data from the Kirov region shows only 20.86% of schools offer two or more foreign languages <snippet id="S_HIjqi4N">. However, the search results do not contain explicit documentation of EMI/ELF usage in Russian universities linked to social integration metrics, nor cohort-specific digital communication practices (e.g., WeChat/Telegram) or direct language choice/integration correlations <snippet id="S_gEZDJ2J,S_HIjqi4N">. Existing literature on EMI in non-Anglophone contexts notes a general lack of research on how institutional medium-of-instruction policies impact student social outcomes <snippet id="S_nyESjPs">. Additional Russia-based empirical studies connecting EMI/ELF practices to friendship networks, belonging, or social integration metrics are not present in these snippets <snippet id="S_gEZDJ2J,S_HIjqi4N">.
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<answer>
<snippet id="95020,20176,28554">The Net 2.0 (2006) is a direct-to-video techno-thriller set in Istanbul about a systems analyst framed via identity theft</snippet>, <snippet id="20176,28554">distributed by Sony Pictures Home Entertainment</snippet>, and <snippet id="95020">is a loose sequel to the 1995 original</snippet>. <snippet id="20176,28554">The plot involves a computer expert who loses identity and bank accounts before clearing her name</snippet>. <snippet id="95020">DVD Talk reviewed the film, describing it as a weak, slow thriller with poor character development</snippet>, though <snippet id="20176,28554">neither the IMDb nor IGN sources identify the composer</snippet>. <snippet id="28554">The IGN review rates the film mediocre (5/10), with video and audio both scoring 7/10</snippet>. <snippet id="95020,28554">The DVD includes an audio commentary with director Charles Winkler and producer Rob Cowan</snippet>.

</answer>

<answer>
<snippet id="95020,20176,28554">The Net 2.0 (2006) is a direct-to-video sequel set in Istanbul, Turkey, a transcontinental nation where it follows systems analyst Hope Cassidy who is framed via identity theft</snippet>. <snippet id="20176,28554">The film was distributed on DVD by Sony Pictures Home Entertainment</snippet>. <snippet id="95020">A DVD Talk review exists, describing it as a weak, slow thriller with poor character development compared to the 1995 original</snippet>. <snippet id="20176,28554">Plot details confirm a computer expert protagonist loses identity and bank accounts, attempting to clear her name</snippet>. <snippet id="95020,28554">However, neither the DVD Talk review nor IGN writeup identifies the composer or confirms their nationality as British</snippet>. <snippet id="95020,20176,28554">The film has received mixed-to-negative reviews, with critics calling the plot predictable and camerawork shaky</snippet>.
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<answer>
<snippet id="S_uhSBIm0,S_0Hoj5Qf,S_PL4DVGG">The Amiga Hardware Reference Manual 3rd Edition is available as a PDF from the Internet Archive and other sources, covering Amiga hardware architecture</snippet>, including <snippet id="S_tLl4qpY">register summaries in alphabetical and address order for coprocessor, playfield, and enhanced chip set hardware</snippet>. <snippet id="S_SqQQ0P3">The Amiga ROM Kernel Reference Manual v1.3 PDF provides system software documentation corresponding to the V1.3 system release</snippet>, which covers Exec, Libraries, and Devices programming interfaces. <snippet id="S_RaUa9ux">The AGA (Amiga Graphics Adapter) documentation specifies maximum 704×510 resolution, 12-bit color depth, and PAL/NTSC support</snippet>. However, <snippet id="S_5opBoeK">the 2nd Edition manual covers older A1000/A500/A2000 machines rather than the A1200 with 8 MB Fast RAM</snippet>, so the 3rd Edition is needed for modern Amiga 1200 architecture. Additional documentation on Amiga Hunk executable format and 68030 cache coherency with DMA would require further searches.
</answer>

<answer>
<snippet id="S_uhSBIm0,S_PL4DVGG,S_0Hoj5Qf">The Amiga Hardware Reference Manual 3rd Edition is available as a PDF and covers the Enhanced Chip Set (AGA) specifications</snippet>, which is essential for understanding AGA custom chips, Copper, Blitter, and DMA capabilities <snippet id="S_tLl4qpY">. Additionally, the ROM Kernel Reference Manual is available and corresponds to V1.3 system software, providing the Exec, Libraries, and OS API documentation</snippet> <snippet id="S_SqQQ0P3">. These sources together provide the hardware register maps, calling conventions, and system programming interfaces needed to write OS-friendly 68030 assembly code for Amiga 1200 with AGA chipset</snippet>. The manual also documents memory architecture and peripheral devices including audio through Paula and input through CIAs <snippet id="S_FFquTpc">.
</answer>


<answer>
<snippet id="S_M4OmJlb">Janus nanopore neuromorphic synapses are emerging as a solution for reservoir computing, addressing the performance bottleneck in von Neumann systems by utilizing two-terminal memory devices that enable high-density, energy-efficient synapse implementations, crucial for applications requiring massive parallelism and error tolerance from 2023 to 2025</snippet>. <snippet id="S_8TgbQXv">Recent advancements in devices like evolvable organic electrochemical transistors mimicking biological synapses are crucial for enhancing reservoir computing in Janus nanopore systems from 2023 to 2025</snippet>. <snippet id="S_yF3B4Ib">While conventional neuromorphic computing relies on solid-state memristive devices based on metal-insulator-metal architectures, aqueous chemimemristors using proton-permeable graphene membranes and nanofluidic devices showing memristive behavior offer alternative bioinspired approaches</snippet>. <snippet id="S_YkA1LR2">For digital neuromorphic hardware, SRAM crossbar arrays are preferred for higher throughput, while analog systems may leverage next-generation memory like ReRAM and memristors for enhanced synaptic weight management in reservoir computing applications from 2023 to 2025</snippet>. <snippet id="S_7aDjN43">Three-terminal synaptic devices including memtransistors and ferroelectric devices are explored as alternatives to traditional two-terminal devices to overcome current leakage and lack of third terminal for precise synaptic weight adjustment</snippet>.
</answer>

<answer>
<snippet id=S_M4OmJlb>Janus nanopore neuromorphic synapses are emerging as a solution for reservoir computing from 2023 to 2025</snippet>, addressing performance bottlenecks by utilizing two-terminal memory devices for high-density, energy-efficient synapse implementations <snippet id=S_M4OmJlb>crucial for applications requiring massive parallelism and error tolerance</snippet>. <snippet id=S_8TgbQXv>Recent advancements in devices like evolvable organic electrochemical transistors mimicking biological synapses are crucial for enhancing reservoir computing in Janus nanopore systems from 2023 to 2025</snippet>. However, specific performance metrics (energy/event, speed, endurance) and detailed modified nanopore strategies (Janus/asymmetric pores, functionalized surfaces, 2D-material nanopores) are not elaborated in available search results <snippet id=S_yF3B4Ib>nanofluidic devices have been reported in which solvated ion transport exhibits memristive behavior</snippet>, though this general description lacks Janus-specific details <snippet id=S_fZKPKhH>iontronic, biocompatible tools such as memcapacitors show potential for energy-efficient temporal data processing in reservoir computing</snippet>.
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<answer>
<snippet id="27111,18506">Raising Sand is the first collaborative studio album by Robert Plant and Alison Krauss, produced by T Bone Burnett and released in October 2007 on Rounder</snippet>. <snippet id="27111,18506">The album debuted at No.2 on the Billboard 200, was RIAA-certified, and earned major Grammy Awards including Album of the Year in 2009</snippet>. <snippet id="27111">It was nominated for the 2008 Mercury Prize and won Record of the Year for "Please Read the Letter"</snippet>. <snippet id="93249">Their later collaboration, Raise the Roof (2021), was the duo's second album together and also received critical acclaim and Grammy nominations</snippet>. <snippet id="18506">Raising Sand remains one of Krauss's three collaboration albums with Plant</snippet>.
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<answer>
<snippet id="27111,18506">Raising Sand is the first collaborative studio album by Robert Plant and Alison Krauss, produced by T Bone Burnett and released in October 2007 on Rounder</snippet>, and <snippet id="18506">it is one of Krauss's three collaboration albums</snippet>. The album debuted at No.2 on the Billboard 200, was certified Platinum in the U.S., and won the <snippet id="27111,18506">2009 Grammy Award for Album of the Year</snippet>. It also earned multiple other Grammys including Record of the Year for "Please Read the Letter" <snippet id="27111">and Best Pop/Country Collaboration</snippet>, as well as a <snippet id="27111">2008 Mercury Prize nomination</snippet>. Later, the duo released a second collaboration album called "Raise the Roof" in 2021 <snippet id="93249">, also produced by T Bone Burnett</snippet>.
</answer>


<answer>
<snippet id="S_ju8QCeq">A double-blind, counterbalanced trial using the Loughborough Intermittent Shuttle Test (LIST) and repeated sprint ability (RSA) tests found no significant differences in average or fastest sprint times between a 6.4% maltodextrin carbohydrate mouth rinse and placebo conditions</snippet>. <snippet id="S_KYkLCMQ">Dorling and Earnest found no significant effect using a 6.4% maltodextrin solution during a non-self-paced LIST protocol</snippet>, though <snippet id="S_kKV6iAs">Rollo and colleagues employed a self-paced LIST protocol with a 10% maltodextrin solution associated with increased self-selected jogging speed and an 86% likelihood of benefiting 15 m sprint performance during the final stages (75-90 min) of exercise compared to placebo</snippet>. <snippet id="S_KYkLCMQ">The concept of "glycostat" suggests chemoreceptors in muscles communicate carbohydrate status to the brain, potentially influencing energy expenditure through central ergogenic effects</snippet>. <snippet id="S_R70LZbT">Most studies indicate that carbohydrate ingestion (typically 30–60 g/h from a 6%–7% solution) enhances intermittent high-intensity exercise capacity, though results regarding its effects on sprinting and other skills are mixed</snippet>. <snippet id="S_DqWoyEo">The Loughborough Intermittent Shuttle Test (LIST) is designed to simulate team sport activity patterns, incorporating acceleration, deceleration, and variable-speed running with physiological responses comparable to professional soccer matches</snippet>. <snippet id="S_a74wEj9">Energy production during brief sprints is derived from degradation of intra-muscular phosphocreatine and glycogen (anaerobic metabolism), with prolonged periods of multiple sprints draining muscle glycogen stores and reducing power output</snippet>.
</answer>

<answer>
<snippet id="S_ju8QCeq">In a study using the Loughborough Intermittent Shuttle Test (LIST) and repeated sprint ability (RSA) tests, carbohydrate mouth rinsing (6.4% Maltodextrin) showed no significant difference in average or fastest sprint times compared to placebo</snippet>. <snippet id="S_KYkLCMQ">However, Rollo and colleagues employed a self-paced LIST protocol with 10% maltodextrin and found increased self-selected jogging speed plus an 86% likelihood of benefiting 15 m sprint performance during the final stages (75-90 min) of exercise</snippet>. <snippet id="S_kKV6iAs">This difference may be because the self-selected pacing protocol provides a more sensitive measure to detect potential benefits of carbohydrate mouth rinsing compared to the non-self-paced version</snippet>. <snippet id="S_R70LZbT">Reviews of carbohydrate supplementation in intermittent sports indicate that results regarding sprinting effects are mixed, with the most significant benefits shown in conditions of fatigue or low blood sugar</snippet>. <snippet id="S_HHafi2O">The evidence for carbohydrate mouth rinsing in intermittent sports is limited with existing research showing inconsistencies due to methodological differences</snippet>.
</answer>


<snippet id=391d2d98-3>According to the search results, there is a record of a "Captain Delauney" role in the West End musical "Erminie" in 1885, though this appears to be a theatrical production rather than a musical comedy</snippet>. <snippet id=391d2d98-0,391d2d98-5>Other search results refer to unrelated entities such as the Eurodance music project "Captain Hollywood Project" and the duo "Captain & Tennille"</snippet>. <snippet id=391d2d98-1>Additionally, "The Sound of Music" is featured in relation to a Delaunay brand, but this is a film celebration rather than a musical role</snippet>. <snippet id=391d2d98-7>The name "Sonia Delaunay" also appears in connection with a Tate Modern art exhibition, which is unrelated to the stage role in question</snippet>.

<answer>
<snippet id=391d2d98-3>Kate Everleigh was a celebrated 19th-century English performer who played Captain Delaunay in the West End hit Erminie in 1885</snippet>. Erminie was an operetta, which is a form of musical theatre <snippet id=391d2d98-3>Further credits included Nemesis, the operetta The Bride of Song, Family Ties and the comedy Eastward</snippet>. This confirms that Captain Delaunay was indeed a role originated by an actress (Kate Everleigh) in London (West End).
</answer>


The search results did not retrieve the specific "Recommendations for reporting on emerging optical imaging agents to promote clinical approval" paper with substantive text, as no snippets contained its full content <snippet id="S_Jgj08Rj">only the title was found</snippet>. However, related regulatory and translational reviews provide context on fluorescence-guided surgery (FGS) approval pathways, noting that indocyanine green (ICG) and fluorescein approvals in 1959 and 1972 serve as foundational milestones for understanding FDA regulatory trends <snippet id="S_PCgmFnG">the article reviews the regulatory pathways for the approval of fluorescence imaging agents and devices used in open-field fluorescence-guided surgery</snippet><snippet id="S_CSlM2L8">Key fluorescent imaging agents, such as indocyanine green (ICG) and fluorescein, were initially approved for different uses before becoming integral to fluorescence imaging</snippet>. These reviews emphasize the importance of learning from past approvals to guide future regulatory applications, highlighting company investments and successful pathways for device clearances <snippet id="S_PCgmFnG">The authors conclude that strategic decisions by developers, based on existing optical fluorescent agents, have facilitated the advancement of device clearances and new drug approvals</snippet><snippet id="S_CSlM2L8">The article emphasizes the importance of learning from past approvals to guide future regulatory applications</snippet>. For clinical translation, challenges include establishing safety profiles, costs associated with clinical trials, and the need for further characterization of targeting moieties to correlate with disease <snippet id="S_x0VNW1o">While many agents show promise for clinical use, their safety profiles and the costs associated with clinical trials pose significant challenges to gaining FDA approval</snippet><snippet id="S_HFIp1yO">The text categorizes chemical agents for translational studies into small-molecule-based, peptide-based, and antibody-based imaging agents, noting a shift towards targeted molecular agents</snippet>. Key performance capabilities for FGS systems include real-time overlay of white-light and fluorescence images, nanomolar-level sensitivity, and quantitative capabilities beyond ICG-only systems <snippet id="S_l2OQQbn">Key evaluation criteria for these instruments include real-time overlay of white-light and fluorescence images, functionality in ambient lighting, nanomolar-level sensitivity, quantitative capabilities, simultaneous imaging of multiple fluorophores</snippet>.

<snippet id="S_Jgj08Rj">The retrieved snippet for "Recommendations for reporting on emerging optical imaging agents to promote clinical approval" contains only the title without substantive text</snippet>. <snippet id="S_1xU5DFw">Other relevant results indicate that clinical adoption of fluorescent probes is hindered by regulatory challenges and the need for further safety assessments</snippet>. <snippet id="S_CSlM2L8">Historical FDA approval milestones reveal that agents like indocyanine green (1959) and fluorescein (1972) were initially vascular flow agents before expanding to surgery</snippet>. <snippet id="S_PCgmFnG">Regulatory pathway reviews emphasize that strategic decisions based on existing optical fluorescent agents facilitate future device clearances and new drug approvals</snippet>. <snippet id="S_1xU5DFw">Essential characteristics for clinical utility include specific binding to disease biomarkers, high signal-to-background ratios, and rapid clearance from non-target tissues</snippet>.


The provided search results do not contain substantive content from the paper "Exploring the possibility space: taking stock of the diverse capabilities and gaps in integrated assessment models." The only snippet with the matching title (S_zF8Pr28) provides only the paper title itself, not abstract, methods, or findings. Other snippets discuss integrated assessment models generally—such as their use in SDG trade-off assessments (S_onh5WOE), urban sustainability contexts (S_ausD8QJ), or climate policy analysis (S_u8Vhij6)—but do not report specific empirical findings or the "possibility space" framework from the target paper. One snippet notes that IAMs integrate diverse knowledge across environmental and socio-economic disciplines but face challenges like high uncertainty and dependency on assumptions (S_CoFf8GZ). Without access to the paper's actual content, I cannot summarize its specific technical contributions or empirical results regarding IAM capabilities and gaps. The agent will need to conduct more targeted searches or directly access the full paper to retrieve the required evidence.

<answer>
The provided search results do not contain substantive content from the paper "Exploring the possibility space: taking stock of the diverse capabilities and gaps in integrated assessment models." The only snippet with the matching title (S_zF8Pr28) provides only the paper title itself, not abstract, methods, or findings. Other snippets discuss integrated assessment models generally—such as their use in SDG trade-off assessments (S_onh5WOE), urban sustainability contexts (S_ausD8QJ), or climate policy analysis (S_u8Vhij6)—but do not report specific empirical findings or the "possibility space" framework from the target paper. Without access to the paper's actual content, I cannot summarize its specific technical contributions or empirical results regarding IAM capabilities and gaps. The agent will need to conduct more targeted searches or directly access the full paper to retrieve the required evidence.
</answer>

<answer>
The search results do not contain substantive content from the target paper "Exploring the possibility space: taking stock of the diverse capabilities and gaps in integrated assessment models" <snippet id="S_zF8Pr28">The search results only show the paper title without abstract, methods, results, or discussion content</snippet>. The available snippets discuss IAMs in general terms from other papers but do not provide evidence about what "possibility space" means in the target paper's framing <snippet id="S_u8Vhij6">IAMs are mostly used for sustainable transformation and development pathway analysis and exploring climate policy and technology options</snippet> <snippet id="S_CoFf8GZ">they face challenges such as high uncertainty and dependency on the quality of underlying assumptions, highlighting both their capabilities and gaps</snippet>. No empirical intercomparison or mapping results from the target paper are present in the retrieved snippets <snippet id="S_zF8Pr28">Only title information is available from the target paper</snippet>. To properly answer the agent's query, additional searches must retrieve the actual paper text with abstract, methods, results, or discussion paragraphs.
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