diff --git a/python/sglang/srt/mem_cache/hiradix_cache.py b/python/sglang/srt/mem_cache/hiradix_cache.py
index f2ed1aea9..75ff08fd6 100644
--- a/python/sglang/srt/mem_cache/hiradix_cache.py
+++ b/python/sglang/srt/mem_cache/hiradix_cache.py
@@ -48,9 +48,9 @@ class HiRadixCache(RadixCache):
 
         if hicache_io_backend == "direct":
             if hicache_mem_layout == "page_first":
-                hicache_mem_layout = "layer_first"
+                hicache_mem_layout = "page_first_direct"
                 logger.warning(
-                    "Page first layout is not supported with direct IO backend, switching to layer first layout"
+                    "Page first layout is not supported with direct IO backend, switching to page first direct layout"
                 )
 
         self.kv_cache = token_to_kv_pool_allocator.get_kvcache()
diff --git a/python/sglang/srt/mem_cache/storage/mooncake_store/mooncake_store.py b/python/sglang/srt/mem_cache/storage/mooncake_store/mooncake_store.py
index 2ea016285..0b9db07f7 100644
--- a/python/sglang/srt/mem_cache/storage/mooncake_store/mooncake_store.py
+++ b/python/sglang/srt/mem_cache/storage/mooncake_store/mooncake_store.py
@@ -190,9 +190,10 @@ class MooncakeStore(HiCacheStorage):
 
     def register_mem_pool_host(self, mem_pool_host: HostKVCache):
         super().register_mem_pool_host(mem_pool_host)
-        assert (
-            self.mem_pool_host.layout == "page_first"
-        ), "mooncake store storage backend only support page first layout"
+        assert self.mem_pool_host.layout in [
+            "page_first",
+            "page_first_direct",
+        ], "mooncake store storage backend only support page first or page first direct layout"
         buffer = self.mem_pool_host.kv_buffer
         try:
             buffer_ptr = buffer.data_ptr()
diff --git a/python/sglang/srt/server_args.py b/python/sglang/srt/server_args.py
index 1535d3a2a..f076b8a1f 100644
--- a/python/sglang/srt/server_args.py
+++ b/python/sglang/srt/server_args.py
@@ -930,8 +930,15 @@ class ServerArgs:
 
     def _handle_hicache(self):
         if self.hicache_storage_backend == "mooncake":
-            self.hicache_io_backend = "kernel"
-            self.hicache_mem_layout = "page_first"
+            if self.hicache_mem_layout == "layer_first":
+                if self.hicache_io_backend == "direct":
+                    self.hicache_mem_layout = "page_first_direct"
+                elif self.hicache_io_backend == "kernel":
+                    self.hicache_mem_layout = "page_first"
+                logger.warning(
+                    f"Mooncake storage backend does not support layer_first layout, "
+                    f"switching to {self.hicache_mem_layout} layout for {self.hicache_io_backend} io backend"
+                )
 
         if self.hicache_mem_layout == "page_first_direct":
             if self.hicache_io_backend != "direct":
diff --git a/test/srt/hicache/test_hicache_storage_mooncake_backend.py b/test/srt/hicache/test_hicache_storage_mooncake_backend.py
index 9e750397a..2f3f94bce 100644
--- a/test/srt/hicache/test_hicache_storage_mooncake_backend.py
+++ b/test/srt/hicache/test_hicache_storage_mooncake_backend.py
@@ -236,6 +236,21 @@ class TestMooncakeBackendPageFirstLayout(
         """Get additional server arguments specific to configuration - override in subclasses"""
         server_args, env_vars = super()._get_additional_server_args_and_env()
         server_args["--hicache-mem-layout"] = "page_first"
+        server_args["--hicache-io-backend"] = "kernel"
+        return server_args, env_vars
+
+
+class TestMooncakeBackendPageFirstDirectLayout(
+    HiCacheStorageMooncakeBackendBaseMixin, CustomTestCase
+):
+    """Page first layout tests for HiCache-Mooncake backend"""
+
+    @classmethod
+    def _get_additional_server_args_and_env(cls):
+        """Get additional server arguments specific to configuration - override in subclasses"""
+        server_args, env_vars = super()._get_additional_server_args_and_env()
+        server_args["--hicache-mem-layout"] = "page_first_direct"
+        server_args["--hicache-io-backend"] = "direct"
         return server_args, env_vars