diff --git a/python/sglang/srt/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X,dtype=float8.json b/python/sglang/srt/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X,dtype=float8.json
new file mode 100644
index 000000000..00434d8e3
--- /dev/null
+++ b/python/sglang/srt/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X,dtype=float8.json
@@ -0,0 +1,57 @@
+{
+   "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 0,
+        "waves_per_eu": 1,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 0,
+        "waves_per_eu": 2,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 0,
+        "waves_per_eu": 1,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 0,
+        "waves_per_eu": 2,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32768": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 0,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    } 
+}